Protein profile

VK055_1648

integrase

Genome: KpATCC43816

Gene: int AIK80268.1 Structure source: ColabFold
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Amino acids 351
Annotations 3
Features 13
PDB binders 0
Druggability 0.286

Overview

Basic information about this protein and its source genome.

Accession
VK055_1648
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
int AIK80268.1
Status
annotated
Amino acids
351
Structure source
ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
38.182
Localization
Cytoplasmic
ColabFold pLDDT
89.45

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.286
Structure CB_VK055_1648
Pocket Pocket 10
P2Rank 0.395
Structure CB_VK055_1648
Pocket Pocket 1
ColabFold model
FPocket 0.286 · Pocket 10
P2Rank 0.395 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
170 329 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
170 329 InterPro IPR002104 Integrase, catalytic domain
169 338 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
169 338 InterPro IPR013762 Integrase-like, catalytic domain superfamily
174 250 Pfam PF00589 Phage integrase family
174 250 InterPro IPR002104 Integrase, catalytic domain
280 320 Pfam PF00589 Phage integrase family
280 320 InterPro IPR002104 Integrase, catalytic domain
59 148 ProSiteProfiles PS51900 Core-binding (CB) domain profile.
59 148 InterPro IPR044068 Core-binding (CB) domain
174 318 CDD cd00796 INT_Rci_Hp1_C
60 326 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
60 326 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1648
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.286
1 0.019
2 0.005
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.66 0.395
2 2.96 0.077
3 1.62 0.022
4 1.37 0.014
5 0.88 0.003