Protein profile

VK055_1650

major Facilitator Superfamily protein

Genome: KpATCC43816

Gene: AIK80270.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUM7
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Amino acids 400
Annotations 3
Features 51
PDB binders 0
Druggability 0.929

Overview

Basic information about this protein and its source genome.

Accession
VK055_1650
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80270.1
Status
annotated
Amino acids
400
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
32.53
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.929
Structure A0A0H3GUM7
Pocket Pocket 19
P2Rank 0.975
Structure A0A0H3GUM7
Pocket Pocket 1
ColabFold model
FPocket 0.766 · Pocket 23
P2Rank 0.968 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 66 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

51 records
Show feature table
Start End DB Term Name
168 190 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
390 400 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
253 275 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
217 234 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
223 387 Pfam PF07690 Major Facilitator Superfamily
223 387 InterPro IPR011701 Major facilitator superfamily
329 339 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
167 171 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
367 389 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
302 306 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125 144 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 31 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 389 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
282 301 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
105 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
145 166 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 50 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
211 395 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
211 395 InterPro IPR036259 MFS transporter superfamily
2 388 PANTHER PTHR23514 BYPASS OF STOP CODON PROTEIN 6
83 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 105 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
235 253 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
307 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
72 82 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
305 327 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 394 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
13 394 InterPro IPR020846 Major facilitator superfamily domain
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 391 SUPERFAMILY SSF103473 MFS general substrate transporter
12 391 InterPro IPR036259 MFS transporter superfamily
84 101 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 195 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
5 195 InterPro IPR036259 MFS transporter superfamily
10 191 FunFam G3DSA:1.20.1250.20:FF:000133 Inner membrane protein YbjJ
359 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
254 275 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
106 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
340 362 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 398 FunFam G3DSA:1.20.1250.20:FF:000102 Inner membrane protein ybjJ
15 377 CDD cd17393 MFS_MosC_like
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
191 216 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
340 358 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
282 301 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 281 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
172 190 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUM7
AlphaFold — — full sequence — Viewing
ColabFold VK055_1650
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
19 0.929
11 0.568
28 0.46

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 39.99 0.963
2 6.67 0.339
3 4.9 0.22
4 3.39 0.121
5 3.06 0.102