Protein profile

VK055_1698

glycosyl transferase family, helical bundle domain protein

Genome: KpATCC43816

Gene: AIK80318.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKD1
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Amino acids 322
Annotations 3
Features 11
PDB binders 0
Druggability 0.584

Overview

Basic information about this protein and its source genome.

Accession
VK055_1698
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80318.1
Status
annotated
Amino acids
322
Structure source
AlphaFold + ColabFold
GO
GO:0004048 Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0000162 The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.584
Structure A0A0H3GKD1
Pocket Pocket 2
P2Rank 0.562
Structure A0A0H3GKD1
Pocket Pocket 1
ColabFold model
FPocket 0.079 · Pocket 18
P2Rank 0.536 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004048 Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.
  • GO:0000162 The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
7 72 SUPERFAMILY SSF47648 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
7 72 InterPro IPR036320 Glycosyl transferase family 3, N-terminal domain superfamily
2 318 PANTHER PTHR43285 ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
2 318 InterPro IPR005940 Anthranilate phosphoribosyl transferase
75 322 SUPERFAMILY SSF52418 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
75 322 InterPro IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
73 322 Gene3D G3DSA:3.40.1030.10 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
73 322 InterPro IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
5 69 Pfam PF02885 Glycosyl transferase family, helical bundle domain
5 69 InterPro IPR017459 Glycosyl transferase family 3, N-terminal domain
1 72 Gene3D G3DSA:1.20.970.10 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKD1
AlphaFold — — full sequence — Viewing
ColabFold VK055_1698
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.584
18 0.012
7 0.005
21 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.33 0.562
2 1.91 0.032
3 0.9 0.003