Metabolic network

VK055_1728

dethiobiotin synthase

Back to protein
Network centrality 0.01543 top 91.9%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Biotin metabolism, more central than 91.9% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Biotin metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

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EC
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN1ZN3-9

EC - · RXN1ZN3-9 · not reversible · 2 isoenzymes

Producing chokepoint
(7R,8S)-diaminononanoate CO2
→
(7R,8S)-8-amino-7-(carboxyamino)nonanoate 2 H+

RXN1ZN3-10

EC - · RXN1ZN3-10 · not reversible · 2 isoenzymes

Consuming chokepoint
(7R,8S)-8-amino-7-(carboxyamino)nonanoate ATP
→
dethiobiotin phosphate ADP H+

Imported from KpATCC43816.sbml · 2026-07-09