Protein profile

VK055_1771

cation diffusion facilitator transporter family protein

Genome: KpATCC43816

Gene: AIK80390.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQC6
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Amino acids 314
Annotations 6
Features 30
PDB binders 0
Druggability 0.562

Overview

Basic information about this protein and its source genome.

Accession
VK055_1771
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80390.1
Status
annotated
Amino acids
314
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324 Enables the transfer of cation from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
41.667
Human E-value
1.63e-17
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.781
DEG E-value
5.74e-75
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.562
Structure A0A0H3GQC6
Pocket Pocket 1
P2Rank 0.461
Structure A0A0H3GQC6
Pocket Pocket 1
ColabFold model
FPocket 0.212 · Pocket 1
P2Rank 0.882 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 93 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.
  • GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
83 107 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 212 FunFam G3DSA:1.20.1510.10:FF:000016 Zinc transporter ZitB
188 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 213 Gene3D G3DSA:1.20.1510.10 Cation efflux protein transmembrane domain
17 213 InterPro IPR027469 Cation efflux transmembrane domain superfamily
108 118 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
183 187 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
53 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 314 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 48 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 213 Pfam PF01545 Cation efflux family
23 213 InterPro IPR002524 Cation efflux protein
8 294 PANTHER PTHR11562 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER
155 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
144 154 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
119 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
72 82 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
18 293 NCBIfam TIGR01297 cation diffusion facilitator family transporter
18 293 InterPro IPR002524 Cation efflux protein
15 214 SUPERFAMILY SSF161111 Cation efflux protein transmembrane domain-like
15 214 InterPro IPR027469 Cation efflux transmembrane domain superfamily
54 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
49 53 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
228 292 SUPERFAMILY SSF160240 Cation efflux protein cytoplasmic domain-like
228 292 InterPro IPR036837 Cation efflux protein, cytoplasmic domain superfamily
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
83 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQC6
AlphaFold — — full sequence — Viewing
ColabFold VK055_1771
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.562
27 0.448
2 0.008
9 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.96 0.461
2 7.58 0.336
3 5.06 0.19
4 2.44 0.054
5 1.95 0.034