Protein profile

VK055_2010

helix-turn-helix family protein

Genome: KpATCC43816

Gene: AIK80616.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KGK0
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Amino acids 119
Annotations 3
Features 14
PDB binders 0
Druggability 0.581

Overview

Basic information about this protein and its source genome.

Accession
VK055_2010
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80616.1
Status
annotated
Amino acids
119
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0001046 Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.537
Localization
Cytoplasmic
ColabFold pLDDT
94.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.581
Structure A0A0C7KGK0
Pocket Pocket 1
P2Rank 0.013
Structure A0A0C7KGK0
Pocket Pocket 1
ColabFold model
FPocket 0.325 · Pocket 1
P2Rank 0.029 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0001046 Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
45 119 Gene3D G3DSA:1.10.260.40 -
45 119 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
64 114 Pfam PF01381 Helix-turn-helix
64 114 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
61 116 CDD cd00093 HTH_XRE
61 116 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
6 117 PANTHER PTHR40455 ANTITOXIN HIGA
6 117 InterPro IPR039060 Antitoxin HigA
60 117 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
60 117 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
62 116 SMART SM00530 mbf_short4
62 116 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
63 116 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
63 116 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KGK0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2010
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.581
8 0.007
6 0.005
9 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.35 0.013