Protein profile

VK055_2119

beta-galactosidase ganA

Genome: KpATCC43816

Gene: ganA AIK80724.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP41
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Amino acids 685
Annotations 6
Features 20
PDB binders 0
Druggability 0.738

Overview

Basic information about this protein and its source genome.

Accession
VK055_2119
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
ganA AIK80724.1
Status
annotated
Amino acids
685
Structure source
AlphaFold + ColabFold
EC
3.2.1.23
GO
GO:0009341 A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. GO:0006012 The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004565 Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.738
Structure A0A0H3GP41
Pocket Pocket 20
P2Rank 0.628
Structure A0A0H3GP41
Pocket Pocket 1
ColabFold model
FPocket 0.41 · Pocket 40
P2Rank 0.624 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 134 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0009341 A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.
  • GO:0006012 The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004565 Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
6 684 PIRSF PIRSF001084 B-galactosidase
6 684 InterPro IPR003476 Glycoside hydrolase, family 42
3 399 Gene3D G3DSA:3.20.20.80 Glycosidases
400 623 Gene3D G3DSA:3.40.50.880 -
400 623 InterPro IPR029062 Class I glutamine amidotransferase-like
626 683 Pfam PF08533 Beta-galactosidase C-terminal domain
626 683 InterPro IPR013739 Beta-galactosidase C-terminal
19 392 Pfam PF02449 Beta-galactosidase
19 392 InterPro IPR013529 Glycoside hydrolase, family 42, N-terminal
10 670 PANTHER PTHR36447 BETA-GALACTOSIDASE GANA
10 670 InterPro IPR003476 Glycoside hydrolase, family 42
401 615 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
401 615 InterPro IPR029062 Class I glutamine amidotransferase-like
624 685 Gene3D G3DSA:2.60.40.1180 -
624 685 InterPro IPR013780 Glycosyl hydrolase, all-beta
6 372 SUPERFAMILY SSF51445 (Trans)glycosidases
6 372 InterPro IPR017853 Glycoside hydrolase superfamily
403 615 Pfam PF08532 Beta-galactosidase trimerisation domain
403 615 InterPro IPR013738 Beta-galactosidase trimerisation
405 531 CDD cd03143 A4_beta-galactosidase_middle_domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP41
AlphaFold — — full sequence — Viewing
ColabFold VK055_2119
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.738
18 0.594
7 0.358

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.02 0.539
2 5.08 0.232
3 3.81 0.148
4 2.62 0.076
5 2.57 0.073