Protein profile

VK055_2120

arabinogalactan endo-1,4-beta-galactosidase

Genome: KpATCC43816

Gene: AIK80725.1 ganB Structure source: AlphaFold + ColabFold UniProt A0A0H3GNN0
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Amino acids 366
Annotations 4
Features 7
PDB binders 0
Druggability 0.461

Overview

Basic information about this protein and its source genome.

Accession
VK055_2120
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80725.1 ganB
Status
annotated
Amino acids
366
Structure source
AlphaFold + ColabFold
EC
3.2.1.89
GO
GO:0015926 Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. GO:0031218 Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.461
Structure A0A0H3GNN0
Pocket Pocket 2
P2Rank 0.904
Structure A0A0H3GNN0
Pocket Pocket 1
ColabFold model
FPocket 0.802 · Pocket 1
P2Rank 0.939 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0015926 Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.
  • GO:0031218 Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans.
  • GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 366 Gene3D G3DSA:3.20.20.80 Glycosidases
2 366 PANTHER PTHR34983 ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A
2 366 InterPro IPR011683 Glycosyl hydrolase family 53
3 365 SUPERFAMILY SSF51445 (Trans)glycosidases
3 365 InterPro IPR017853 Glycoside hydrolase superfamily
6 365 Pfam PF07745 Glycosyl hydrolase family 53
6 365 InterPro IPR011683 Glycosyl hydrolase family 53

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNN0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2120
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.461
1 0.004
6 0.003
4 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.49 0.904
2 2.87 0.073
3 1.17 0.009