Protein profile

VK055_2157

bolA transcriptional regulator BolA transcriptional dual regulator

Genome: KpATCC43816

Gene: bolA AIK80762.1 Structure source: ColabFold
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Amino acids 88
Annotations 0
Features 10
PDB binders 0
Druggability 0.922

Overview

Basic information about this protein and its source genome.

Accession
VK055_2157
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
bolA AIK80762.1
Status
annotated
Amino acids
88
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
46.341
Human E-value
3.82e-20
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.619
DEG E-value
4.93e-22
Localization
Unknown
ColabFold pLDDT
83.18

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.922
Structure CB_VK055_2157
Pocket Pocket 3
P2Rank 0.341
Structure CB_VK055_2157
Pocket Pocket 1
ColabFold model
FPocket 0.922 · Pocket 3
P2Rank 0.341 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 126 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 72 FunFam G3DSA:3.30.300.90:FF:000001 Transcriptional regulator BolA
2 72 SUPERFAMILY SSF82657 BolA-like
2 72 InterPro IPR036065 BolA-like superfamily
1 83 PIRSF PIRSF003113 BolA
1 83 InterPro IPR002634 BolA protein
2 84 PANTHER PTHR46229 BOLA TRANSCRIPTION REGULATOR
2 67 Pfam PF01722 BolA-like protein
2 67 InterPro IPR002634 BolA protein
1 73 Gene3D G3DSA:3.30.300.90 -
1 73 InterPro IPR036065 BolA-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_2157
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.922

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.06 0.102
2 2.0 0.043