Amino acids
264
Annotations
8
Features
36
PDB binders
0
Druggability
0.451
Overview
Basic information about this protein and its source genome.
- Accession
- VK055_2160
- Gene
- AIK80765.1 cyoA
- Status
- annotated
- Amino acids
- 264
- Structure source
- AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005507 Binding to a copper (Cu) ion.
GO:0009486 Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space].
GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
GO:0016682 Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 56.067
- DEG E-value
- 8.61e-104
- Localization
- CytoplasmicMembrane
- ColabFold pLDDT
- 84.32
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.451
P2Rank
0.009
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
147 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
8 GO
Gene Ontology (GO)
8- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0005507 Binding to a copper (Cu) ion.
- GO:0009486 Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space].
- GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
- GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
- GO:0016682 Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen.
- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0042773 The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.
Sequence Features
Domain/signature hits from InterPro and related databases.
36 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 66 | SUPERFAMILY | SSF81464 | Cytochrome c oxidase subunit II-like, transmembrane region |
| 1 | 66 | InterPro | IPR036257 | Cytochrome C oxidase subunit II, transmembrane domain superfamily |
| 3 | 11 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 12 | 16 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 4 | 21 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 40 | 58 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 74 | 187 | ProSiteProfiles | PS50857 | Cytochrome oxidase subunit II copper A binding domain profile. |
| 74 | 187 | InterPro | IPR002429 | Cytochrome c oxidase subunit II-like C-terminal |
| 17 | 39 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 2 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 1 | 189 | NCBIfam | TIGR01433 | ubiquinol oxidase subunit II |
| 1 | 189 | InterPro | IPR006333 | Cytochrome o ubiquinol oxidase subunit II |
| 77 | 175 | CDD | cd04212 | CuRO_UO_II |
| 77 | 175 | InterPro | IPR034227 | Ubiquinol oxidase subunit 2, cupredoxin domain |
| 41 | 58 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 68 | ProSiteProfiles | PS50999 | Cytochrome oxidase subunit II transmembrane region profile. |
| 1 | 68 | InterPro | IPR011759 | Cytochrome C oxidase subunit II, transmembrane domain |
| 63 | 232 | FunFam | G3DSA:2.60.40.420:FF:000008 | Ubiquinol oxidase subunit 2 |
| 72 | 232 | SUPERFAMILY | SSF49503 | Cupredoxins |
| 72 | 232 | InterPro | IPR008972 | Cupredoxin |
| 59 | 264 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 2 | 192 | PANTHER | PTHR22888 | CYTOCHROME C OXIDASE, SUBUNIT II |
| 2 | 192 | InterPro | IPR045187 | Cytochrome c/quinol oxidase subunit II |
| 189 | 234 | Pfam | PF06481 | COX Aromatic Rich Motif |
| 189 | 234 | InterPro | IPR010514 | COX aromatic rich motif |
| 63 | 232 | Gene3D | G3DSA:2.60.40.420 | - |
| 63 | 232 | InterPro | IPR008972 | Cupredoxin |
| 1 | 262 | PIRSF | PIRSF000292 | Ubiqnol_oxid_II |
| 1 | 262 | InterPro | IPR006333 | Cytochrome o ubiquinol oxidase subunit II |
| 99 | 168 | Pfam | PF00116 | Cytochrome C oxidase subunit II, periplasmic domain |
| 99 | 168 | InterPro | IPR002429 | Cytochrome c oxidase subunit II-like C-terminal |
| 1 | 16 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 1 | 62 | Gene3D | G3DSA:1.10.287.90 | - |
| 1 | 62 | InterPro | IPR036257 | Cytochrome C oxidase subunit II, transmembrane domain superfamily |
| 239 | 264 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 236 | 264 | MobiDBLite | mobidb-lite | consensus disorder prediction |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GP15
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
VK055_2160
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 14 | 0.189 | ||||||
| 1 | 0.108 | ||||||
| 7 | 0.022 | ||||||
| 10 | 0.01 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 1.2 | 0.009 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 2 | 0.031 | ||||||
| 13 | 0.027 | ||||||
| 3 | 0.006 | ||||||
| 15 | 0.003 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 1.41 | 0.015 |