Protein profile

VK055_2200

hypothetical protein

Genome: KpATCC43816

Gene: AIK80805.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNZ2
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Amino acids 193
Annotations 3
Features 13
PDB binders 0
Druggability 0.029

Overview

Basic information about this protein and its source genome.

Accession
VK055_2200
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80805.1
Status
annotated
Amino acids
193
Structure source
AlphaFold + ColabFold
EC
3.1.4.14
GO
GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.029
Structure A0A0H3GNZ2
Pocket Pocket 9
P2Rank 0.436
Structure A0A0H3GNZ2
Pocket Pocket 1
ColabFold model
FPocket 0.037 · Pocket 11
P2Rank 0.661 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
  • GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
81 185 Pfam PF04336 Acyl carrier protein phosphodiesterase
81 185 InterPro IPR007431 Acyl carrier protein phosphodiesterase
16 193 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 192 PANTHER PTHR38764 ACYL CARRIER PROTEIN PHOSPHODIESTERASE
1 192 InterPro IPR007431 Acyl carrier protein phosphodiesterase
1 193 PIRSF PIRSF011489 UCP011489
1 193 InterPro IPR007431 Acyl carrier protein phosphodiesterase
1 193 Hamap MF_01950 Acyl carrier protein phosphodiesterase [acpH].
1 193 InterPro IPR023491 Acyl carrier protein phosphodiesterase, gammaproteobacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNZ2
AlphaFold — — full sequence — Viewing
ColabFold VK055_2200
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.83 0.35
2 4.08 0.164
3 1.27 0.013