Protein profile

VK055_2285

transcriptional regulatory, C terminal family protein

Genome: KpATCC43816

Gene: AIK80889.1 Structure source: AlphaFold + ColabFold UniProt A0ABD7NPZ0
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Amino acids 266
Annotations 3
Features 16
PDB binders 0
Druggability 0.356

Overview

Basic information about this protein and its source genome.

Accession
VK055_2285
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80889.1
Status
annotated
Amino acids
266
Structure source
AlphaFold + ColabFold
GO
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
34.234
Localization
Unknown
ColabFold pLDDT
82.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.356
Structure A0ABD7NPZ0
Pocket Pocket 7
P2Rank
Structure A0ABD7NPZ0
Pocket No pockets
ColabFold model
FPocket 0.292 · Pocket 12
P2Rank 0.01 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
37 105 Pfam PF00486 Transcriptional regulatory protein, C terminal
37 105 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 151 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27 105 SMART SM00862 Trans_reg_C_3
27 105 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
9 111 Gene3D G3DSA:1.10.10.10 -
9 111 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
153 175 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 107 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
2 107 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
26 105 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
26 105 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
177 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38 105 CDD cd00383 trans_reg_C
38 105 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
152 176 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0ABD7NPZ0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2285
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.356
10 0.009
5 0.001
2 0.0