Protein profile

VK055_2288

type VII secretion system (T7SS), usher family protein

Genome: KpATCC43816

Gene: AIK80892.1 Structure source: AlphaFold + ColabFold UniProt A0ABD7NQR9
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Amino acids 877
Annotations 5
Features 26
PDB binders 0
Druggability 0.327

Overview

Basic information about this protein and its source genome.

Accession
VK055_2288
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80892.1
Status
annotated
Amino acids
877
Structure source
AlphaFold + ColabFold
GO
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.773
DEG E-value
0.0
Localization
OuterMembrane
ColabFold pLDDT
88.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.327
Structure A0ABD7NQR9
Pocket Pocket 22
P2Rank 0.569
Structure A0ABD7NQR9
Pocket Pocket 1
ColabFold model
FPocket 0.368 · Pocket 6
P2Rank 0.598 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
795 877 Gene3D G3DSA:2.60.40.2070 -
795 877 InterPro IPR043142 PapC-like, C-terminal domain superfamily
795 877 FunFam G3DSA:2.60.40.2070:FF:000001 Fimbrial outer membrane usher protein
207 789 Pfam PF00577 Outer membrane usher protein
207 789 InterPro IPR000015 Outer membrane usher protein
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
324 334 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
324 334 InterPro IPR018030 Fimbrial membrane usher, conserved site
23 876 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
23 876 InterPro IPR000015 Outer membrane usher protein
704 794 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
41 877 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
704 794 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
704 794 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
282 371 Gene3D G3DSA:2.60.40.3110 -
798 861 Pfam PF13953 PapC C-terminal domain
798 861 InterPro IPR025949 PapC-like, C-terminal domain
70 183 SUPERFAMILY SSF141729 FimD N-terminal domain-like
70 183 InterPro IPR037224 PapC, N-terminal domain superfamily
282 371 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
45 169 Gene3D G3DSA:3.10.20.410 -
45 169 InterPro IPR037224 PapC, N-terminal domain superfamily
47 191 Pfam PF13954 PapC N-terminal domain
47 191 InterPro IPR025885 PapC, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0ABD7NQR9
AlphaFold — — full sequence — Viewing
ColabFold VK055_2288
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.049
42 0.003
4 0.001
79 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.53 0.569
2 6.03 0.247
3 2.63 0.062
4 2.55 0.058
5 2.36 0.05