Metabolic network

VK055_2450

dihydrolipoyl dehydrogenase

Back to protein
Network centrality 0.04343 top 95.1%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing & consuming chokepoint reaction, more central than 95.1% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

No specific KEGG pathway assigned - this reaction either has no KEGG mapping, or only matches a generic overview map with no route-level information.

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Pathway
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

1.8.1.4-RXN

EC 1.8.1.4 · 1.8.1.4-RXN · not reversible · 2 isoenzymes

a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine NAD+
→
a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine NADH H+

RXN-7716

EC 1.8.1.4 · RXN-7716 · not reversible · 2 isoenzymes

a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine NAD+
→
a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine NADH H+

RXN-7719

EC 1.8.1.4 · RXN-7719 · reversible · 2 isoenzymes

an [apo BCAA dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine NAD+
⇌
a [BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine NADH H+

RXN-8629

EC 1.8.1.4 · RXN-8629 · reversible · 3 isoenzymes

a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine NAD+
⇌
a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine NADH H+

RXN0-1132

EC 1.8.1.4 · RXN0-1132 · not reversible · 2 isoenzymes

a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine NAD+
→
a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine NADH H+

RXN-22437

EC - · RXN-22437 · not reversible · 3 isoenzymes

Producing & consuming chokepoint
an [acetoin dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine NAD+
→
an [acetoin dehydrogenase E2 protein] N6-lipoyl-L-lysine NADH H+

Imported from KpATCC43816.sbml · 2026-07-09