Protein profile

VK055_2457

alpha-N-arabinofuranosidase 2

Genome: KpATCC43816

Gene: AIK81054.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMN3
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Amino acids 316
Annotations 2
Features 10
PDB binders 0
Druggability 0.734

Overview

Basic information about this protein and its source genome.

Accession
VK055_2457
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81054.1
Status
annotated
Amino acids
316
Structure source
AlphaFold + ColabFold
GO
GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.734
Structure A0A0H3GMN3
Pocket Pocket 1
P2Rank 0.899
Structure A0A0H3GMN3
Pocket Pocket 1
ColabFold model
FPocket 0.695 · Pocket 1
P2Rank 0.936 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 151 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
5 311 SUPERFAMILY SSF75005 Arabinanase/levansucrase/invertase
5 311 InterPro IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain superfamily
13 276 CDD cd18817 GH43f_LbAraf43-like
2 313 Gene3D G3DSA:2.115.10.20 Glycosyl hydrolase domain; family 43
2 313 InterPro IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain superfamily
3 311 PANTHER PTHR43817 GLYCOSYL HYDROLASE
5 306 Pfam PF04616 Glycosyl hydrolases family 43
5 306 InterPro IPR006710 Glycoside hydrolase, family 43
1 316 PIRSF PIRSF025414 Alpha-N-AFase
1 316 InterPro IPR016828 Alpha-L-arabinofuranosidase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMN3
AlphaFold — — full sequence — Viewing
ColabFold VK055_2457
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.734

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.47 0.881
2 4.29 0.177
3 1.18 0.01
4 0.93 0.004