Protein profile

VK055_2499

major Facilitator Superfamily protein

Genome: KpATCC43816

Gene: AIK81096.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN71

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Amino acids 404

Annotations 4

Features 51

PDB binders 0

Druggability 0.403

Overview

Basic information about this protein and its source genome.

Accession: VK055_2499
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK81096.1
Status: annotated
Amino acids: 404
Structure source: AlphaFold + ColabFold

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 58.105
DEG E-value: 7.369999999999999e-165
Localization: CytoplasmicMembrane
ColabFold pLDDT: 89.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.403

Structure A0A0H3GN71

Pocket Pocket 2

P2Rank 0.938

Structure A0A0H3GN71

Pocket Pocket 1

ColabFold model

FPocket 0.856 · Pocket 6

P2Rank 0.952 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 41 / 4744 genomes with a hit

Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

51 records

Show feature table

Start	End	DB	Term	Name
179	210	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
61	77	ProSitePatterns	PS00216	Sugar transport proteins signature 1.
61	77	InterPro	IPR005829	Sugar transporter, conserved site
213	235	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
8	389	ProSiteProfiles	PS50850	Major facilitator superfamily (MFS) profile.
8	389	InterPro	IPR020846	Major facilitator superfamily domain
233	243	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
270	275	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95	111	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
276	298	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
5	27	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	192	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
4	192	InterPro	IPR036259	MFS transporter superfamily
132	153	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
66	71	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12	31	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
207	389	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
207	389	InterPro	IPR036259	MFS transporter superfamily
154	158	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
244	269	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
299	303	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
42	64	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
9	390	SUPERFAMILY	SSF103473	MFS general substrate transporter
9	390	InterPro	IPR036259	MFS transporter superfamily
90	94	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
112	131	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2	394	PANTHER	PTHR23514	BYPASS OF STOP CODON PROTEIN 6
159	178	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
132	154	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
43	65	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
337	354	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
32	42	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
72	89	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
276	298	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
361	386	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
211	232	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
73	90	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
304	326	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
250	269	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
94	111	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
387	404	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
158	180	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	190	FunFam	G3DSA:1.20.1250.20:FF:000135	MFS family transporter
364	386	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	352	Pfam	PF07690	Major Facilitator Superfamily
13	352	InterPro	IPR011701	Major facilitator superfamily
302	324	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
338	355	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
327	337	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
356	360	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GN71	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_2499	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
27				0.402
1				0.378
28				0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	36.86	0.938
2	4.98	0.186
3	3.1	0.083
4	2.7	0.065
5	1.69	0.024

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.235
20				0.017
1				0.006
19				0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	41.92	0.952
2	4.88	0.18
3	2.13	0.041
4	1.38	0.014
5	1.23	0.01