Protein profile

VK055_2537

triphosphoribosyl-dephospho-CoA synthase CitG

Genome: KpATCC43816

Gene: AIK81134.1 citG Structure source: AlphaFold + ColabFold UniProt A0A0H3GME2
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Amino acids 302
Annotations 6
Features 11
PDB binders 0
Druggability 0.501

Overview

Basic information about this protein and its source genome.

Accession
VK055_2537
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81134.1 citG
Status
annotated
Amino acids
302
Structure source
AlphaFold + ColabFold
EC
2.4.2.52
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.501
Structure A0A0H3GME2
Pocket Pocket 2
P2Rank 0.947
Structure A0A0H3GME2
Pocket Pocket 1
ColabFold model
FPocket 0.037 · Pocket 2
P2Rank 0.952 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine.
  • GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
  • GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
160 295 Gene3D G3DSA:1.10.4200.10 -
47 159 Gene3D G3DSA:1.10.4200.10 -
47 295 FunFam G3DSA:1.10.4200.10:FF:000001 Triphosphoribosyl-dephospho-CoA synthase CitG
1 302 Hamap MF_00397 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase [citG].
1 302 InterPro IPR017551 Triphosphoribosyl-dephospho-CoA synthase CitG
14 297 PANTHER PTHR30201 TRIPHOSPHORIBOSYL-DEPHOSPHO-COA SYNTHASE
14 297 InterPro IPR002736 Triphosphoribosyl-dephospho-CoA protein
21 293 NCBIfam TIGR03125 triphosphoribosyl-dephospho-CoA synthase CitG
21 293 InterPro IPR017551 Triphosphoribosyl-dephospho-CoA synthase CitG
25 291 Pfam PF01874 ATP:dephospho-CoA triphosphoribosyl transferase
25 291 InterPro IPR002736 Triphosphoribosyl-dephospho-CoA protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GME2
AlphaFold — — full sequence — Viewing
ColabFold VK055_2537
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.501

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.87 0.875
2 3.36 0.119