Protein profile

VK055_2540

citrate lyase acyl carrier protein

Genome: KpATCC43816

Gene: AIK81137.1 citD Structure source: AlphaFold + ColabFold UniProt A0A0H3GJ19
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Amino acids 97
Annotations 2
Features 7
PDB binders 0
Druggability 0.42

Overview

Basic information about this protein and its source genome.

Accession
VK055_2540
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81137.1 citD
Status
annotated
Amino acids
97
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
55.67
DEG E-value
4.62e-31
Localization
Cytoplasmic
ColabFold pLDDT
95.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.42
Structure A0A0H3GJ19
Pocket Pocket 1
P2Rank
Structure A0A0H3GJ19
Pocket No pockets
ColabFold model
FPocket 0.527 · Pocket 3
P2Rank 0.013 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 130 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
6 86 Pfam PF06857 Malonate decarboxylase delta subunit (MdcD)
6 86 InterPro IPR023439 Malonate decarboxylase/citrate lyase acyl carrier protein
1 97 PIRSF PIRSF002736 Citrt_lyas_gamma
1 97 InterPro IPR006495 Citrate lyase acyl carrier protein CitD
1 97 Hamap MF_00805 Citrate lyase acyl carrier protein [citD].
1 94 NCBIfam TIGR01608 citrate lyase acyl carrier protein
1 94 InterPro IPR006495 Citrate lyase acyl carrier protein CitD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJ19
AlphaFold — — full sequence — Viewing
ColabFold VK055_2540
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.42
4 0.042
3 0.003
2 0.0