Protein profile

VK055_2567

amino acid carrier family protein

Genome: KpATCC43816

Gene: AIK81164.1 agcS Structure source: AlphaFold + ColabFold UniProt A0A0H3GI03
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Amino acids 476
Annotations 5
Features 54
PDB binders 0
Druggability 0.638

Overview

Basic information about this protein and its source genome.

Accession
VK055_2567
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81164.1 agcS
Status
annotated
Amino acids
476
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.13
DEG E-value
3.3600000000000003e-125
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.638
Structure A0A0H3GI03
Pocket Pocket 21
P2Rank 0.307
Structure A0A0H3GI03
Pocket Pocket 1
ColabFold model
FPocket 0.803 · Pocket 14
P2Rank 0.935 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 99 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

54 records
Show feature table
Start End DB Term Name
228 232 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
301 323 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 50 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
386 408 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
233 256 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
87 102 ProSitePatterns PS00873 Sodium:alanine symporter family signature.
87 102 InterPro IPR001463 Sodium:alanine symporter
342 370 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
74 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
117 136 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
257 300 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
343 365 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 453 Pfam PF01235 Sodium:alanine symporter family
52 453 InterPro IPR001463 Sodium:alanine symporter
371 390 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
207 229 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
195 205 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
439 476 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
206 225 PRINTS PR00175 Sodium/alanine symporter signature
206 225 InterPro IPR001463 Sodium:alanine symporter
410 430 PRINTS PR00175 Sodium/alanine symporter signature
410 430 InterPro IPR001463 Sodium:alanine symporter
303 321 PRINTS PR00175 Sodium/alanine symporter signature
303 321 InterPro IPR001463 Sodium:alanine symporter
178 196 PRINTS PR00175 Sodium/alanine symporter signature
178 196 InterPro IPR001463 Sodium:alanine symporter
87 109 PRINTS PR00175 Sodium/alanine symporter signature
87 109 InterPro IPR001463 Sodium:alanine symporter
349 371 PRINTS PR00175 Sodium/alanine symporter signature
349 371 InterPro IPR001463 Sodium:alanine symporter
93 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
169 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
51 73 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
323 341 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
172 194 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 227 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
137 157 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 453 FunFam G3DSA:1.20.1740.10:FF:000004 Sodium:alanine symporter family protein
414 436 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 458 PANTHER PTHR30330 AGSS FAMILY TRANSPORTER, SODIUM-ALANINE
2 458 InterPro IPR001463 Sodium:alanine symporter
410 414 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
137 159 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
57 455 Gene3D G3DSA:1.20.1740.10 Amino acid/polyamine transporter I
301 322 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
158 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 441 NCBIfam TIGR00835 amino acid carrier protein
13 441 InterPro IPR001463 Sodium:alanine symporter
415 438 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
391 409 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI03
AlphaFold — — full sequence — Viewing
ColabFold VK055_2567
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.121
2 0.019
1 0.007
12 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.07 0.307
2 6.6 0.281
3 5.71 0.229
4 4.42 0.154
5 3.59 0.107