Protein profile

VK055_2599

BON domain protein

Genome: KpATCC43816

Gene: AIK81196.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIU5
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Amino acids 198
Annotations 1
Features 24
PDB binders 0
Druggability 0.112

Overview

Basic information about this protein and its source genome.

Accession
VK055_2599
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81196.1
Status
annotated
Amino acids
198
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.135
Localization
Periplasmic
ColabFold pLDDT
81.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.112
Structure A0A0H3GIU5
Pocket Pocket 6
P2Rank
Structure A0A0H3GIU5
Pocket No pockets
ColabFold model
FPocket 0.457 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
24 122 PANTHER PTHR34606 BON DOMAIN-CONTAINING PROTEIN
1 16 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
2 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
51 116 Gene3D G3DSA:3.30.1340.30 -
133 198 Gene3D G3DSA:3.30.1340.30 -
13 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
51 116 FunFam G3DSA:3.30.1340.30:FF:000001 Molecular chaperone OsmY
133 198 FunFam G3DSA:3.30.1340.30:FF:000001 Molecular chaperone OsmY
49 117 ProSiteProfiles PS50914 BON domain profile.
49 117 InterPro IPR007055 BON domain
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
131 198 ProSiteProfiles PS50914 BON domain profile.
131 198 InterPro IPR007055 BON domain
132 198 Pfam PF04972 BON domain
132 198 InterPro IPR007055 BON domain
49 115 Pfam PF04972 BON domain
49 115 InterPro IPR007055 BON domain
1 16 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
54 117 SMART SM00749 bon
54 117 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
136 197 SMART SM00749 bon
136 197 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
17 198 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIU5
AlphaFold — — full sequence — Viewing
ColabFold VK055_2599
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer