Protein profile

VK055_2614

bglJ transcriptional regulator domain protein

Genome: KpATCC43816

Gene: bglJ AIK81208.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GM70
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Amino acids 207
Annotations 2
Features 19
PDB binders 0
Druggability 0.067

Overview

Basic information about this protein and its source genome.

Accession
VK055_2614
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
bglJ AIK81208.1
Status
annotated
Amino acids
207
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.105
Localization
Cytoplasmic
ColabFold pLDDT
80.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.067
Structure A0A0H3GM70
Pocket Pocket 1
P2Rank 0.111
Structure A0A0H3GM70
Pocket Pocket 1
ColabFold model
FPocket 0.166 · Pocket 21
P2Rank 0.669 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
164 176 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
164 176 InterPro IPR000792 Transcription regulator LuxR, C-terminal
134 148 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
134 148 InterPro IPR000792 Transcription regulator LuxR, C-terminal
148 164 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
148 164 InterPro IPR000792 Transcription regulator LuxR, C-terminal
49 187 PANTHER PTHR44688 -
134 188 CDD cd06170 LuxR_C_like
134 188 InterPro IPR000792 Transcription regulator LuxR, C-terminal
122 187 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
122 187 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
97 191 Gene3D G3DSA:1.10.10.10 -
97 191 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
127 192 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
127 192 InterPro IPR000792 Transcription regulator LuxR, C-terminal
131 188 SMART SM00421 luxrmega5
131 188 InterPro IPR000792 Transcription regulator LuxR, C-terminal
132 184 Pfam PF00196 Bacterial regulatory proteins, luxR family
132 184 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM70
AlphaFold — — full sequence — Viewing
ColabFold VK055_2614
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.7 0.141
2 2.02 0.044