Protein profile

VK055_2615

putative DNA-binding transcriptional regulator

Genome: KpATCC43816

Gene: AIK81209.1 Structure source: AlphaFold + ColabFold UniProt A0A2X3E6D6
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Amino acids 164
Annotations 2
Features 20
PDB binders 0
Druggability 0.484

Overview

Basic information about this protein and its source genome.

Accession
VK055_2615
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81209.1
Status
annotated
Amino acids
164
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.516
DEG E-value
3.99e-62
Localization
Unknown
ColabFold pLDDT
74.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.484
Structure A0A2X3E6D6
Pocket Pocket 3
P2Rank
Structure A0A2X3E6D6
Pocket No pockets
ColabFold model
FPocket 0.165 · Pocket 9
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
78 92 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
78 92 InterPro IPR000792 Transcription regulator LuxR, C-terminal
92 108 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
92 108 InterPro IPR000792 Transcription regulator LuxR, C-terminal
108 120 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
108 120 InterPro IPR000792 Transcription regulator LuxR, C-terminal
77 131 Pfam PF00196 Bacterial regulatory proteins, luxR family
77 131 InterPro IPR000792 Transcription regulator LuxR, C-terminal
40 134 PANTHER PTHR43214 TWO-COMPONENT RESPONSE REGULATOR
40 134 InterPro IPR039420 Transcriptional regulatory protein WalR-like
36 138 Gene3D G3DSA:1.10.10.10 -
36 138 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
71 136 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
71 136 InterPro IPR000792 Transcription regulator LuxR, C-terminal
78 134 CDD cd06170 LuxR_C_like
78 134 InterPro IPR000792 Transcription regulator LuxR, C-terminal
69 133 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
69 133 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
75 132 SMART SM00421 luxrmega5
75 132 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2X3E6D6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2615
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.359
2 0.186
4 0.055
1 0.002