Protein profile

VK055_2624

sulfatase family protein

Genome: KpATCC43816

Gene: AIK81218.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GM60
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Amino acids 750
Annotations 1
Features 18
PDB binders 0
Druggability 0.986

Overview

Basic information about this protein and its source genome.

Accession
VK055_2624
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81218.1
Status
annotated
Amino acids
750
Structure source
AlphaFold + ColabFold
GO
GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
22.222
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.986
Structure A0A0H3GM60
Pocket Pocket 10
P2Rank 0.954
Structure A0A0H3GM60
Pocket Pocket 1
ColabFold model
FPocket 0.455 · Pocket 46
P2Rank 0.966 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
97 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
150 433 CDD cd16015 LTA_synthase
150 433 Pfam PF00884 Sulfatase
150 433 InterPro IPR000917 Sulfatase, N-terminal
141 436 Gene3D G3DSA:3.40.720.10 Alkaline Phosphatase, subunit A
141 436 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 554 PANTHER PTHR47371 LIPOTEICHOIC ACID SYNTHASE
86 96 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
116 750 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
149 456 SUPERFAMILY SSF53649 Alkaline phosphatase-like
149 456 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
35 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
63 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
63 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM60
AlphaFold — — full sequence — Viewing
ColabFold VK055_2624
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.986

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.94 0.933
2 2.46 0.068
3 1.91 0.039
4 1.91 0.039
5 1.69 0.029