Protein profile

VK055_2665

cobalamin synthesis cobW C-terminal domain protein

Genome: KpATCC43816

Gene: AIK81259.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIL6
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Amino acids 318
Annotations 3
Features 21
PDB binders 0
Druggability 0.62

Overview

Basic information about this protein and its source genome.

Accession
VK055_2665
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81259.1
Status
annotated
Amino acids
318
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
48.611
Human E-value
1.09e-13
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.054
Localization
Cytoplasmic
ColabFold pLDDT
89.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.62
Structure A0A0H3GIL6
Pocket Pocket 4
P2Rank 0.296
Structure A0A0H3GIL6
Pocket Pocket 1
ColabFold model
FPocket 0.472 · Pocket 4
P2Rank 0.414 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 93 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
3 201 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
3 201 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
23 318 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 182 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain
6 182 InterPro IPR003495 CobW/HypB/UreG, nucleotide-binding domain
224 317 SMART SM00833 CobW_C_3
224 317 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
224 315 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain
224 315 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
1 202 Gene3D G3DSA:3.40.50.300 -
1 202 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
224 315 SUPERFAMILY SSF90002 Hypothetical protein YjiA, C-terminal domain
2 314 PANTHER PTHR13748 COBW-RELATED
6 198 CDD cd03112 CobW-like
203 317 Gene3D G3DSA:3.30.1220.10 -
203 317 InterPro IPR036627 CobW-like, C-terminal domain superfamily
1 202 FunFam G3DSA:3.40.50.300:FF:000778 GTP-binding protein YjiA
16 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIL6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2665
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.368
1 0.004
7 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.87 0.296
2 5.14 0.195
3 3.29 0.092
4 2.54 0.058
5 2.36 0.05