Protein profile

VK055_2722

xylose isomerase

Genome: KpATCC43816

Gene: xylA2 AIK81312.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR15
Export view
Amino acids 439
Annotations 6
Features 30
PDB binders 0
Druggability 0.634

Overview

Basic information about this protein and its source genome.

Accession
VK055_2722
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
xylA2 AIK81312.1
Status
annotated
Amino acids
439
Structure source
AlphaFold + ColabFold
EC
5.3.1.5
GO
GO:0009045 Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000287 Binding to a magnesium (Mg) ion. GO:0042732 The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
66.819
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.86

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.634
Structure A0A0H3GR15
Pocket Pocket 3
P2Rank 0.942
Structure A0A0H3GR15
Pocket Pocket 1
ColabFold model
FPocket 0.945 · Pocket 1
P2Rank 0.932 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 201 / 4744 genomes with a hit
Normalized 0.042

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0009045 Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0042732 The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
4 437 NCBIfam TIGR02630 xylose isomerase
4 437 InterPro IPR013452 Xylose isomerase, bacterial-type
3 437 PANTHER PTHR48306 XYLOSE ISOMERASE
3 437 InterPro IPR013452 Xylose isomerase, bacterial-type
3 439 Gene3D G3DSA:3.20.20.150 -
4 438 SUPERFAMILY SSF51658 Xylose isomerase-like
4 438 InterPro IPR036237 Xylose isomerase-like superfamily
11 437 Hamap MF_00455 Xylose isomerase [xylA].
11 437 InterPro IPR001998 Xylose isomerase
133 153 PRINTS PR00688 Xylose isomerase signature
133 153 InterPro IPR001998 Xylose isomerase
180 201 PRINTS PR00688 Xylose isomerase signature
180 201 InterPro IPR001998 Xylose isomerase
207 226 PRINTS PR00688 Xylose isomerase signature
207 226 InterPro IPR001998 Xylose isomerase
156 175 PRINTS PR00688 Xylose isomerase signature
156 175 InterPro IPR001998 Xylose isomerase
300 311 PRINTS PR00688 Xylose isomerase signature
300 311 InterPro IPR001998 Xylose isomerase
333 344 PRINTS PR00688 Xylose isomerase signature
333 344 InterPro IPR001998 Xylose isomerase
271 298 PRINTS PR00688 Xylose isomerase signature
271 298 InterPro IPR001998 Xylose isomerase
92 114 PRINTS PR00688 Xylose isomerase signature
92 114 InterPro IPR001998 Xylose isomerase
229 253 PRINTS PR00688 Xylose isomerase signature
229 253 InterPro IPR001998 Xylose isomerase
2 439 FunFam G3DSA:3.20.20.150:FF:000002 Xylose isomerase
35 437 ProSiteProfiles PS51415 Xylose isomerase family profile.
35 437 InterPro IPR001998 Xylose isomerase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR15
AlphaFold — — full sequence — Viewing
ColabFold VK055_2722
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.609
30 0.12
25 0.003
5 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 38.45 0.942
2 5.76 0.232
3 2.54 0.058
4 1.97 0.035
5 1.77 0.027