Protein profile

VK055_2740

pglZ domain protein

Genome: KpATCC43816

Gene: AIK81330.1 Structure source: AlphaFold + ColabFold UniProt A0A483I1B6
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Amino acids 865
Annotations 0
Features 6
PDB binders 0
Druggability 0.392

Overview

Basic information about this protein and its source genome.

Accession
VK055_2740
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81330.1
Status
annotated
Amino acids
865
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.392
Structure A0A483I1B6
Pocket Pocket 3
P2Rank 0.446
Structure A0A483I1B6
Pocket Pocket 1
ColabFold model
FPocket 0.821 · Pocket 1
P2Rank 0.501 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
4 856 NCBIfam TIGR02687 BREX-1 system phosphatase PglZ type A
4 856 InterPro IPR014060 Alkaline phosphatase-like protein PglZ
474 649 Pfam PF08665 PglZ domain
474 649 InterPro IPR013973 PglZ domain
474 652 SUPERFAMILY SSF53649 Alkaline phosphatase-like
474 652 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483I1B6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2740
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
74 0.353
1 0.272
6 0.057
7 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.64 0.446
2 5.74 0.231
3 5.39 0.21
4 4.32 0.148
5 3.83 0.12