Protein profile

VK055_2747

radical SAM superfamily protein

Genome: KpATCC43816

Gene: AIK81337.1 Structure source: AlphaFold + ColabFold UniProt A0A422ZFZ1
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Amino acids 370
Annotations 3
Features 15
PDB binders 0
Druggability 0.409

Overview

Basic information about this protein and its source genome.

Accession
VK055_2747
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81337.1
Status
annotated
Amino acids
370
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.409
Structure A0A422ZFZ1
Pocket Pocket 4
P2Rank 0.955
Structure A0A422ZFZ1
Pocket Pocket 1
ColabFold model
FPocket 0.449 · Pocket 1
P2Rank 0.962 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
85 349 Gene3D G3DSA:3.20.20.70 Aldolase class I
85 349 InterPro IPR013785 Aldolase-type TIM barrel
95 353 SUPERFAMILY SSF102114 Radical SAM enzymes
95 275 CDD cd01335 Radical_SAM
68 358 NCBIfam TIGR03977 His-Xaa-Ser system radical SAM maturase HxsC
68 358 InterPro IPR024032 His-Xaa-Ser system radical SAM maturase HxsC
89 301 SFLD SFLDG01067 SPASM/twitch domain containing
4 369 SFLD SFLDG01103 Uncharacterised Radical SAM Subgroup 16
4 369 InterPro IPR024032 His-Xaa-Ser system radical SAM maturase HxsC
96 240 Pfam PF04055 Radical SAM superfamily
96 240 InterPro IPR007197 Radical SAM
98 185 Pfam PF13394 4Fe-4S single cluster domain
94 304 PANTHER PTHR11228 RADICAL SAM DOMAIN PROTEIN
4 369 SFLD SFLDS00029 Radical SAM
4 369 InterPro IPR007197 Radical SAM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422ZFZ1
AlphaFold — — full sequence — Viewing
ColabFold VK055_2747
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.409
7 0.373
2 0.003
26 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 43.76 0.955
2 7.32 0.321
3 5.93 0.241
4 2.42 0.053
5 1.29 0.012