Protein profile

VK055_2824

2-dehydro-3-deoxyphosphogluconate aldolase

Genome: KpATCC43816

Gene: AIK81413.1 Structure source: Experimental + ColabFold UniProt A6THF7
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Amino acids 246
Annotations 0
Features 7
PDB binders 0
Druggability 0.706

Overview

Basic information about this protein and its source genome.

Accession
VK055_2824
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81413.1
Status
annotated
Amino acids
246
Structure source
Experimental + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
98.41

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.706
Structure 3M0Z
Pocket Pocket 1
P2Rank 0.605
Structure 3M0Z
Pocket Pocket 1
ColabFold model
FPocket 0.939 · Pocket 1
P2Rank 0.366 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 174 / 4744 genomes with a hit
Normalized 0.037

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
8 225 Pfam PF07071 KDGP aldolase
8 225 InterPro IPR010763 2-dehydro-3-deoxy-phosphogluconate aldolase
1 246 Gene3D G3DSA:3.20.20.70 Aldolase class I
1 246 InterPro IPR013785 Aldolase-type TIM barrel
8 243 NCBIfam TIGR03581 conserved hypothetical protein EF_0839/AHA_3917
8 243 InterPro IPR010763 2-dehydro-3-deoxy-phosphogluconate aldolase
50 205 SUPERFAMILY SSF51569 Aldolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3M0Z
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_2824
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.874
5 0.396

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 19.69 0.843
2 11.68 0.621
3 11.32 0.605
4 8.9 0.476
5 8.6 0.459