Protein profile

VK055_2997

fimbrial family protein

Genome: KpATCC43816

Gene: AIK81582.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQA4
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Amino acids 185
Annotations 3
Features 15
PDB binders 0
Druggability 0.094

Overview

Basic information about this protein and its source genome.

Accession
VK055_2997
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81582.1
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold
GO
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
29.891
Localization
Extracellular
ColabFold pLDDT
83.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.094
Structure A0A0H3GQA4
Pocket Pocket 10
P2Rank 0.554
Structure A0A0H3GQA4
Pocket Pocket 1
ColabFold model
FPocket 0.034 · Pocket 2
P2Rank 0.619 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
25 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region
1 32 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
10 184 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
1 32 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 185 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 184 SUPERFAMILY SSF49401 Bacterial adhesins
35 184 InterPro IPR008966 Adhesion domain superfamily
37 184 Pfam PF00419 Fimbrial protein
37 184 InterPro IPR000259 Fimbrial-type adhesion domain
32 184 Gene3D G3DSA:2.60.40.1090 -
32 184 InterPro IPR036937 Fimbrial-type adhesion domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQA4
AlphaFold — — full sequence — Viewing
ColabFold VK055_2997
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.49 0.51
2 1.16 0.009