Protein profile

VK055_3014

metallo-beta-lactamase superfamily protein

Genome: KpATCC43816

Gene: AIK81599.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHL8
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Amino acids 256
Annotations 1
Features 8
PDB binders 0
Druggability 0.445

Overview

Basic information about this protein and its source genome.

Accession
VK055_3014
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81599.1
Status
annotated
Amino acids
256
Structure source
AlphaFold + ColabFold
GO
GO:0042781 Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.183
Localization
Unknown
ColabFold pLDDT
95.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.445
Structure A0A0H3GHL8
Pocket Pocket 8
P2Rank 0.469
Structure A0A0H3GHL8
Pocket Pocket 1
ColabFold model
FPocket 0.446 · Pocket 7
P2Rank 0.437 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042781 Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 92 PANTHER PTHR46018 ZINC PHOSPHODIESTERASE ELAC PROTEIN 1
32 213 Pfam PF12706 Beta-lactamase superfamily domain
32 213 InterPro IPR001279 Metallo-beta-lactamase
1 245 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
1 245 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
5 180 CDD cd16272 RNaseZ_MBL-fold
2 252 Gene3D G3DSA:3.60.15.10 -
2 252 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHL8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3014
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.249
3 0.003
6 0.001
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.14 0.469
2 4.88 0.18