Protein profile

VK055_3052

malF

Genome: KpATCC43816

Gene: AIK81637.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGU7

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Amino acids 496

Annotations 5

Features 44

PDB binders 0

Druggability 0.51

Overview

Basic information about this protein and its source genome.

Accession: VK055_3052
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK81637.1
Status: annotated
Amino acids: 496
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060 Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. GO:0015423 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 28.058
Localization: CytoplasmicMembrane
ColabFold pLDDT: 91.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.51

Structure A0A0H3GGU7

Pocket Pocket 25

P2Rank 0.734

Structure A0A0H3GGU7

Pocket Pocket 1

ColabFold model

FPocket 0.861 · Pocket 26

P2Rank 0.692 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 106 / 4744 genomes with a hit

Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:1990060 Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK.
GO:0015423 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in).
GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records

Show feature table

Start	End	DB	Term	Name
466	488	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
301	323	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	21	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
252	496	FunFam	G3DSA:1.10.3720.10:FF:000030	Maltose ABC transporter permease MalF
286	296	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	77	Gene3D	G3DSA:1.20.58.370	-
1	77	InterPro	IPR035277	MalF, N-terminal
352	374	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
49	73	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
41	48	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
323	352	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
80	250	Gene3D	G3DSA:3.10.650.10	-
281	480	CDD	cd06261	TM_PBP2
281	480	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
353	374	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
50	72	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
263	487	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
263	487	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
15	37	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
279	483	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
279	483	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
395	418	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
82	242	Pfam	PF14785	Maltose transport system permease protein MalF P2 domain
82	242	InterPro	IPR029345	Maltose transport system permease protein MalF, P2 domain
266	288	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	495	PANTHER	PTHR47314	MALTOSE/MALTODEXTRIN TRANSPORT SYSTEM PERMEASE PROTEIN MALF
259	285	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
466	488	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
489	496	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
252	496	Gene3D	G3DSA:1.10.3720.10	-
252	496	InterPro	IPR035906	MetI-like superfamily
100	187	FunFam	G3DSA:2.40.430.10:FF:000001	Maltose ABC transporter permease MalF
1	77	FunFam	G3DSA:1.20.58.370:FF:000001	Maltose ABC transporter permease MalF
297	322	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
395	417	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
419	465	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
375	394	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
22	40	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
243	485	SUPERFAMILY	SSF161098	MetI-like
243	485	InterPro	IPR035906	MetI-like superfamily
74	258	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
100	187	Gene3D	G3DSA:2.40.430.10	-
100	187	InterPro	IPR047103	Maltose transport system permease protein MalF, P2 domain superfamily
2	242	SUPERFAMILY	SSF160964	MalF N-terminal region-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GGU7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_3052	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
25				0.51
15				0.185
6				0.0
13				0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	17.73	0.734
2	10.41	0.482
3	7.09	0.308
4	1.82	0.029
5	1.75	0.026

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
26				0.861
8				0.514
1				0.105
27				0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	16.13	0.692
2	8.38	0.38
3	6.06	0.248
4	2.89	0.074
5	1.42	0.015