Protein profile

VK055_3143

twin arginine-targeting protein translocase TatB

Genome: KpATCC43816

Gene: tatB AIK81715.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKG8
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Amino acids 178
Annotations 4
Features 19
PDB binders 0
Druggability 0.506

Overview

Basic information about this protein and its source genome.

Accession
VK055_3143
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
tatB AIK81715.1
Status
annotated
Amino acids
178
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
43.478
Localization
CytoplasmicMembrane
ColabFold pLDDT
71.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.506
Structure A0A0H3GKG8
Pocket Pocket 16
P2Rank
Structure A0A0H3GKG8
Pocket No pockets
ColabFold model
FPocket 0.427 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
  • GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.
  • GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 153 Hamap MF_00237 Sec-independent protein translocase protein TatB [tatB].
1 153 InterPro IPR018448 Sec-independent protein translocase protein TatB
2 80 NCBIfam TIGR01410 Sec-independent protein translocase protein TatB
2 80 InterPro IPR018448 Sec-independent protein translocase protein TatB
9 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
81 106 MobiDBLite mobidb-lite consensus disorder prediction
21 40 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature
40 58 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature
1 21 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature
1 139 PANTHER PTHR33162 SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA, CHLOROPLASTIC
1 49 Gene3D G3DSA:1.20.5.3310 -
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
154 178 MobiDBLite mobidb-lite consensus disorder prediction
29 178 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
81 178 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKG8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3143
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.028
18 0.007
1 0.006
3 0.006