Protein profile

VK055_3189

UDP-N-acetylglucosamine 2-epimerase

Genome: KpATCC43816

Gene: AIK81757.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKC6
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Amino acids 361
Annotations 4
Features 13
PDB binders 1
Druggability 0.306

Overview

Basic information about this protein and its source genome.

Accession
VK055_3189
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81757.1
Status
annotated
Amino acids
361
Structure source
AlphaFold + ColabFold
EC
5.1.3.14
GO
GO:0008761 Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
22.051
Human E-value
4.11e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
82.548
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.03

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.306
Structure A0A0H3GKC6
Pocket Pocket 24
P2Rank 0.983
Structure A0A0H3GKC6
Pocket Pocket 1
ColabFold model
FPocket 0.267 · Pocket 26
P2Rank 0.987 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1243 / 4744 genomes with a hit
Normalized 0.262

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0008761 Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.
  • GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 355 CDD cd03786 GTB_UDP-GlcNAc_2-Epimerase
1 357 NCBIfam TIGR00236 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)
1 357 InterPro IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like
1 356 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
1 359 PANTHER PTHR43174 UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE
1 359 InterPro IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like
1 359 Hamap MF_02028 UDP-N-acetylglucosamine 2-epimerase [wecB].
1 359 InterPro IPR032892 UDP-N-acetylglucosamine 2-epimerase WecB
1 176 FunFam G3DSA:3.40.50.2000:FF:000043 UDP-N-acetylglucosamine 2-epimerase
1 351 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
172 341 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
7 355 Pfam PF02350 UDP-N-acetylglucosamine 2-epimerase
7 355 InterPro IPR003331 UDP-N-acetylglucosamine 2-epimerase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKC6
AlphaFold — — full sequence — Viewing
ColabFold VK055_3189
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
24 0.306
1 0.054
15 0.013
25 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 61.79 0.983
2 4.48 0.157
3 1.81 0.028
4 1.2 0.009

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
UD1
6VLC
A0A0U1RGY0 607.4 Da LogP -4.65 TPSA 305.9 3 viol. ✓ Clean CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[P@@]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.