Protein profile

VK055_3234

fructose-6-phosphate aldolase

Genome: KpATCC43816

Gene: AIK81795.1 fsa Structure source: AlphaFold + ColabFold UniProt A0A0H3GH01
Export view
Amino acids 220
Annotations 7
Features 18
PDB binders 11
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
VK055_3234
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81795.1 fsa
Status
annotated
Amino acids
220
Structure source
AlphaFold + ColabFold
EC
4.1.2.-
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097023 Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate. GO:0006000 The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. GO:0042182 The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.963
Localization
Cytoplasmic
ColabFold pLDDT
97.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure A0A0H3GH01
Pocket Pocket 1
P2Rank 0.272
Structure A0A0H3GH01
Pocket Pocket 1
ColabFold model
FPocket 0.624 · Pocket 11
P2Rank 0.173 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0097023 Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate.
  • GO:0006000 The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
  • GO:0042182 The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
60 209 PANTHER PTHR10683 TRANSALDOLASE
60 209 InterPro IPR001585 Transaldolase/Fructose-6-phosphate aldolase
2 212 CDD cd00956 Transaldolase_FSA
2 212 InterPro IPR033919 Transaldolase/Fructose-6-phosphate aldolase, archaeal/bacterial
24 32 ProSitePatterns PS01054 Transaldolase signature 1.
24 32 InterPro IPR018225 Transaldolase, active site
1 218 SUPERFAMILY SSF51569 Aldolase
1 215 NCBIfam TIGR00875 fructose-6-phosphate aldolase
1 215 InterPro IPR004731 Transaldolase type 3B/Fructose-6-phosphate aldolase
1 220 Hamap MF_00496 Fructose-6-phosphate aldolase [fsa].
1 220 InterPro IPR023001 Fructose-6-phosphate aldolase
1 217 FunFam G3DSA:3.20.20.70:FF:000018 Probable transaldolase
82 99 ProSitePatterns PS00958 Transaldolase active site.
82 99 InterPro IPR018225 Transaldolase, active site
3 206 Pfam PF00923 Transaldolase/Fructose-6-phosphate aldolase
3 206 InterPro IPR001585 Transaldolase/Fructose-6-phosphate aldolase
1 219 Gene3D G3DSA:3.20.20.70 Aldolase class I
1 219 InterPro IPR013785 Aldolase-type TIM barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH01
AlphaFold — — full sequence — Viewing
ColabFold VK055_3234
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.737

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.26 0.114
2 1.76 0.032

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

61 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
44S
4S2B
P0A870 244.1 Da LogP -2.08 TPSA 136.7 ✓ Ro5 ✓ Clean C1[C@H]([C@@H](O[C@H]1O)[C@@H](COP(=O)(O)O)O)O
4Y8
5ZOL
P78055 74.1 Da LogP -0.43 TPSA 37.3 ✓ Ro5 ✓ Clean CC(=O)CO
A5P
3UPB
Q5NFX0 232.1 Da LogP -2.83 TPSA 147.7 1 viol. ✓ Clean C([C@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O)O
E4P
3S1U
Q9HKI3 200.1 Da LogP -1.98 TPSA 124.3 ✓ Ro5 ✓ Clean C([C@H]([C@H](C=O)O)O)OP(=O)(O)O
F6R
4S2C
P0A870 260.1 Da LogP -3.26 TPSA 164.8 1 viol. ✓ Clean C([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)OP(=O)(O)O
FLC
3S1W
Q9HKI3 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
G3P
4XZ9
Q9HKI3 172.1 Da LogP -1.55 TPSA 107.2 ✓ Ro5 ✓ Clean C([C@H](COP(=O)(O)O)O)O
I22
3TKF
Q5NFX0 290.2 Da LogP -3.90 TPSA 185.0 1 viol. ✓ Clean C([C@H]([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)O)OP(=…
LW1
5ZOL
P78055 112.2 Da LogP 1.56 TPSA 17.1 ✓ Ro5 ✓ Clean c1cc(sc1)C=O
LW2
5ZOL
P78055 186.2 Da LogP 0.73 TPSA 57.5 ✓ Ro5 ✓ Clean CC(=O)[C@H]([C@@H](c1cccs1)O)O
P2D
4S1F
P78055 100.1 Da LogP 0.55 TPSA 34.1 ✓ Ro5 ✓ Clean CC(=O)CC(=O)C

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.