Protein profile

VK055_3287

ribbon-helix-helix, copG family protein

Genome: KpATCC43816

Gene: AIK81848.1 Structure source: Experimental + ColabFold UniProt W9BQC4
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Amino acids 74
Annotations 2
Features 6
PDB binders 0
Druggability 0.333

Overview

Basic information about this protein and its source genome.

Accession
VK055_3287
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81848.1
Status
annotated
Amino acids
74
Structure source
Experimental + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
50.0
Localization
Cytoplasmic
ColabFold pLDDT
80.74

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.333
Structure 7BY3
Pocket Pocket 3
P2Rank
Structure 7BY3
Pocket No pockets
ColabFold model
FPocket 0.713 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
28 48 Coils Coil Coil
3 43 CDD cd21631 RHH_CopG_NikR-like
10 41 Pfam PF12651 Ribbon-helix-helix domain
10 41 InterPro IPR038733 Predicted DNA-binding protein, ribbon-helix-helix domain
1 55 Gene3D G3DSA:1.10.1220.10 -
1 55 InterPro IPR013321 Arc-type ribbon-helix-helix

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7BY3
X-ray 2.00 Å A,C
100.0% 1-74
PDBe RCSB PDBj File
Viewing
PDB 7BY2
X-ray 2.60 Å A
100.0% 1-74
PDBe RCSB PDBj File
Loaded
ColabFold VK055_3287
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.805
1 0.702
3 0.211

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.58 0.133
2 2.04 0.045
3 1.66 0.028
4 1.61 0.026
5 1.22 0.011