Protein profile

VK055_3302

acyltransferase family protein

Genome: KpATCC43816

Gene: AIK81863.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGT7
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Amino acids 299
Annotations 3
Features 19
PDB binders 0
Druggability 0.888

Overview

Basic information about this protein and its source genome.

Accession
VK055_3302
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81863.1
Status
annotated
Amino acids
299
Structure source
AlphaFold + ColabFold
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
23.009
Human E-value
6.19e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
38.697
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.888
Structure A0A0H3GGT7
Pocket Pocket 4
P2Rank 0.983
Structure A0A0H3GGT7
Pocket Pocket 1
ColabFold model
FPocket 0.462 · Pocket 2
P2Rank 0.927 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 82 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
141 299 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67 86 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
122 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
46 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 291 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
88 215 SMART SM00563 plsc_2
88 215 InterPro IPR002123 Phospholipid/glycerol acyltransferase
72 249 CDD cd07990 LPLAT_LCLAT1-like
121 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 120 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15 295 PANTHER PTHR10983 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED
75 211 Pfam PF01553 Acyltransferase
75 211 InterPro IPR002123 Phospholipid/glycerol acyltransferase
87 109 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 45 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGT7
AlphaFold — — full sequence — Viewing
ColabFold VK055_3302
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.888

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 44.25 0.971
2 5.81 0.284
3 3.07 0.102
4 2.62 0.076