Protein profile

VK055_3367

2-oxo-3-deoxygalactonate kinase

Genome: KpATCC43816

Gene: dgoK AIK81924.1 Structure source: AlphaFold + ColabFold UniProt A0A378ARN8
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Amino acids 247
Annotations 2
Features 4
PDB binders 0
Druggability 0.943

Overview

Basic information about this protein and its source genome.

Accession
VK055_3367
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
dgoK AIK81924.1
Status
annotated
Amino acids
247
Structure source
AlphaFold + ColabFold
GO
GO:0008671 Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194 The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
97.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.943
Structure A0A378ARN8
Pocket Pocket 1
P2Rank 0.368
Structure A0A378ARN8
Pocket Pocket 1
ColabFold model
FPocket 0.782 · Pocket 4
P2Rank 0.389 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008671 Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+.
  • GO:0034194 The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
45 247 Gene3D G3DSA:3.30.420.310 -
45 247 InterPro IPR042257 2-keto-3-deoxy-galactonokinase, C-terminal domain
2 241 Pfam PF05035 2-keto-3-deoxy-galactonokinase
2 241 InterPro IPR007729 2-keto-3-deoxy-galactonokinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A378ARN8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3367
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.943
7 0.224

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.08 0.232