Protein profile

VK055_3435

hypothetical protein

Genome: KpATCC43816

Gene: AIK81992.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0A3
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Amino acids 178
Annotations 1
Features 11
PDB binders 0
Druggability 0.648

Overview

Basic information about this protein and its source genome.

Accession
VK055_3435
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81992.1
Status
annotated
Amino acids
178
Structure source
AlphaFold + ColabFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
27.219
Localization
Unknown
ColabFold pLDDT
96.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.648
Structure A0A0H3H0A3
Pocket Pocket 1
P2Rank 0.923
Structure A0A0H3H0A3
Pocket Pocket 1
ColabFold model
FPocket 0.687 · Pocket 2
P2Rank 0.901 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
59 105 NCBIfam TIGR00778 alkylhydroperoxidase AhpD family core domain
59 105 InterPro IPR004675 Alkylhydroperoxidase AhpD core
1 176 SUPERFAMILY SSF69118 AhpD-like
1 176 InterPro IPR029032 AhpD-like
2 172 PANTHER PTHR35446 SI:CH211-175M2.5
2 171 NCBIfam TIGR01926 peroxidase-related enzyme
2 171 InterPro IPR010195 Uncharacterised peroxidase-related
15 176 Gene3D G3DSA:1.20.1290.10 -
15 176 InterPro IPR029032 AhpD-like
51 104 Pfam PF02627 Carboxymuconolactone decarboxylase family
51 104 InterPro IPR003779 Carboxymuconolactone decarboxylase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0A3
AlphaFold — — full sequence — Viewing
ColabFold VK055_3435
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.648
3 0.002
4 0.002
9 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 33.61 0.923
2 1.34 0.013
3 1.25 0.011