Protein profile

VK055_3482

hlyD secretion family protein

Genome: KpATCC43816

Gene: AIK82038.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4J7
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Amino acids 295
Annotations 1
Features 5
PDB binders 0
Druggability 0.402

Overview

Basic information about this protein and its source genome.

Accession
VK055_3482
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82038.1
Status
annotated
Amino acids
295
Structure source
AlphaFold + ColabFold
GO
GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.402
Structure A0A0H3H4J7
Pocket Pocket 1
P2Rank 0.006
Structure A0A0H3H4J7
Pocket Pocket 1
ColabFold model
FPocket 0.809 · Pocket 9
P2Rank 0.023 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 4 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030313 An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
111 138 Coils Coil Coil
186 293 Gene3D G3DSA:2.40.30.170 -
74 140 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
19 295 PANTHER PTHR32347 EFFLUX SYSTEM COMPONENT YKNX-RELATED
172 252 Pfam PF13437 HlyD family secretion protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4J7
AlphaFold — — full sequence — Viewing
ColabFold VK055_3482
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.402
19 0.155
5 0.032
20 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.03 0.006
2 0.98 0.005