Protein profile

VK055_3488

cell division inhibitor

Genome: KpATCC43816

Gene: ttk AIK82044.1 Structure source: Experimental + ColabFold UniProt A6TFN2
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Amino acids 198
Annotations 2
Features 16
PDB binders 0
Druggability 0.11

Overview

Basic information about this protein and its source genome.

Accession
VK055_3488
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
ttk AIK82044.1
Status
annotated
Amino acids
198
Structure source
Experimental + ColabFold
GO
GO:0010974 Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.02

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.11
Structure 5HSZ
Pocket Pocket 2
P2Rank
Structure 5HSZ
Pocket No pockets
ColabFold model
FPocket 0.472 · Pocket 1
P2Rank 0.038 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0010974 Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
118 138 Coils Coil Coil
1 198 Hamap MF_01839 Nucleoid occlusion factor SlmA [slmA].
1 198 InterPro IPR023769 Nucleoid occlusion factor SlmA
10 70 ProSiteProfiles PS50977 TetR-type HTH domain profile.
10 70 InterPro IPR001647 DNA-binding HTH domain, TetR-type
20 61 Pfam PF00440 Bacterial regulatory proteins, tetR family
20 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
84 192 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
84 192 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
5 86 SUPERFAMILY SSF46689 Homeodomain-like
5 86 InterPro IPR009057 Homeobox-like domain superfamily
3 193 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
9 198 FunFam G3DSA:1.10.357.10:FF:000002 Nucleoid occlusion factor SlmA
28 58 ProSitePatterns PS01081 TetR-type HTH domain signature.
28 58 InterPro IPR023772 DNA-binding HTH domain, TetR-type, conserved site
9 198 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5HSZ
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_3488
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.586

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.55 0.072
2 2.05 0.045
3 1.4 0.018
4 1.11 0.008