Protein profile

VK055_3504

O-Antigen ligase family protein

Genome: KpATCC43816

Gene: AIK82060.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4H7

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Amino acids 360

Annotations 1

Features 36

PDB binders 0

Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession: VK055_3504
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK82060.1
Status: annotated
Amino acids: 360
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 29.688
Localization: CytoplasmicMembrane
ColabFold pLDDT: 90.54

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87

Structure A0A0H3H4H7

Pocket Pocket 28

P2Rank 0.425

Structure A0A0H3H4H7

Pocket Pocket 1

ColabFold model

FPocket 0.676 · Pocket 6

P2Rank 0.464 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 9 / 4744 genomes with a hit

Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records

Show feature table

Start	End	DB	Term	Name
314	334	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
40	57	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
178	194	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
131	150	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
280	302	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
340	357	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
199	218	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
157	172	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
39	57	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
92	111	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
112	130	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
199	219	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
281	302	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
314	336	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
220	280	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
173	177	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	23	SignalP_EUK	SignalP-TM	SignalP-TM
131	150	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
24	38	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	7	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
177	194	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
19	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
195	198	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92	111	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	350	PANTHER	PTHR37422	TEICHURONIC ACID BIOSYNTHESIS PROTEIN TUAE
303	313	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67	85	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
335	339	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
151	156	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8	18	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
155	172	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
58	91	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
358	360	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
162	294	Pfam	PF04932	O-Antigen ligase
162	294	InterPro	IPR007016	O-antigen ligase-related

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3H4H7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_3504	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
28				0.87
16				0.413
6				0.319
29				0.25

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	4.9	0.221
2	3.44	0.124
3	1.97	0.042
4	1.37	0.016
5	1.28	0.013

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
16				0.417
5				0.283
2				0.241
20				0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	8.72	0.466
2	2.64	0.077
3	1.69	0.029
4	1.46	0.02
5	1.07	0.007