Protein profile

VK055_3560

acetyltransferase family protein

Genome: KpATCC43816

Gene: AIK82117.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4D0
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Amino acids 146
Annotations 1
Features 14
PDB binders 0
Druggability 0.523

Overview

Basic information about this protein and its source genome.

Accession
VK055_3560
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82117.1
Status
annotated
Amino acids
146
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
37.333
Localization
Unknown
ColabFold pLDDT
94.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.523
Structure A0A0H3H4D0
Pocket Pocket 1
P2Rank 0.962
Structure A0A0H3H4D0
Pocket Pocket 1
ColabFold model
FPocket 0.273 · Pocket 4
P2Rank 0.964 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
19 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
2 125 PANTHER PTHR43800 PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB
1 140 Gene3D G3DSA:3.40.630.30 -
25 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
47 121 Pfam PF13673 Acetyltransferase (GNAT) domain
47 121 InterPro IPR000182 GNAT domain
51 96 CDD cd04301 NAT_SF
1 141 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 141 InterPro IPR016181 Acyl-CoA N-acyltransferase
1 143 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
1 143 InterPro IPR000182 GNAT domain
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4D0
AlphaFold — — full sequence — Viewing
ColabFold VK055_3560
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.276
2 0.001
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 46.74 0.962