Protein profile

VK055_3587

bacterial cellulose synthase subunit

Genome: KpATCC43816

Gene: AIK82142.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYM8
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Amino acids 767
Annotations 4
Features 23
PDB binders 0
Druggability 0.64

Overview

Basic information about this protein and its source genome.

Accession
VK055_3587
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82142.1
Status
annotated
Amino acids
767
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.041
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.64
Structure A0A0H3GYM8
Pocket Pocket 16
P2Rank 0.475
Structure A0A0H3GYM8
Pocket Pocket 1
ColabFold model
FPocket 0.543 · Pocket 37
P2Rank 0.305 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 78 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
517 536 PRINTS PR01440 Cellulose synthase subunit B signature
517 536 InterPro IPR003920 Cellulose synthase, subunit B
88 109 PRINTS PR01440 Cellulose synthase subunit B signature
88 109 InterPro IPR003920 Cellulose synthase, subunit B
301 322 PRINTS PR01440 Cellulose synthase subunit B signature
301 322 InterPro IPR003920 Cellulose synthase, subunit B
178 199 PRINTS PR01440 Cellulose synthase subunit B signature
178 199 InterPro IPR003920 Cellulose synthase, subunit B
220 243 PRINTS PR01440 Cellulose synthase subunit B signature
220 243 InterPro IPR003920 Cellulose synthase, subunit B
384 405 PRINTS PR01440 Cellulose synthase subunit B signature
384 405 InterPro IPR003920 Cellulose synthase, subunit B
752 767 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
350 509 Gene3D G3DSA:2.60.120.260 -
52 763 PANTHER PTHR39083 CYCLIC DI-GMP-BINDING PROTEIN
52 763 InterPro IPR018513 Cellulose synthase BcsB, bacterial
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
63 191 Gene3D G3DSA:2.60.120.260 -
59 668 Pfam PF03170 Bacterial cellulose synthase subunit
59 668 InterPro IPR018513 Cellulose synthase BcsB, bacterial
1 732 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
732 751 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
733 751 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYM8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3587
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
57 0.023
1 0.01
54 0.0
56 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.27 0.475
2 5.58 0.222
3 3.74 0.115
4 3.45 0.099
5 2.81 0.07