Protein profile

VK055_3637

putative membrane protein

Genome: KpATCC43816

Gene: AIK82192.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUD9
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Amino acids 119
Annotations 0
Features 10
PDB binders 0
Druggability 0.323

Overview

Basic information about this protein and its source genome.

Accession
VK055_3637
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82192.1
Status
annotated
Amino acids
119
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.304
DEG E-value
2.8300000000000007e-59
Localization
Unknown
ColabFold pLDDT
82.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.323
Structure A0A0H3GUD9
Pocket Pocket 5
P2Rank
Structure A0A0H3GUD9
Pocket No pockets
ColabFold model
FPocket 0.549 · Pocket 6
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 44 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
5 116 Pfam PF10694 Protein of unknown function (DUF2500)
5 116 InterPro IPR019635 Protein of unknown function DUF2500
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
1 19 SignalP_EUK SignalP-TM SignalP-TM
23 119 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 119 Gene3D G3DSA:2.40.50.660 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUD9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3637
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.029
10 0.002
1 0.0
3 0.0