Protein profile

VK055_3693

hypothetical protein

Genome: KpATCC43816

Gene: AIK82248.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWT0
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Amino acids 45
Annotations 1
Features 5
PDB binders 0
Druggability 0.403

Overview

Basic information about this protein and its source genome.

Accession
VK055_3693
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82248.1
Status
annotated
Amino acids
45
Structure source
AlphaFold + ColabFold
GO
GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.5
DEG E-value
5.11e-06
Localization
Unknown
ColabFold pLDDT
88.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.403
Structure A0A0H3GWT0
Pocket Pocket 4
P2Rank
Structure A0A0H3GWT0
Pocket No pockets
ColabFold model
FPocket 0.274 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 42 PANTHER PTHR42954 FE(2+) TRANSPORT PROTEIN A
1 45 Gene3D G3DSA:2.30.30.90 -
1 45 InterPro IPR038157 Ferrous iron transporter, core domain
1 42 SUPERFAMILY SSF50037 C-terminal domain of transcriptional repressors
1 42 InterPro IPR008988 Transcriptional repressor, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWT0
AlphaFold — — full sequence — Viewing
ColabFold VK055_3693
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.403
3 0.011
5 0.001
1 0.0