Protein profile

VK055_3695

transcription elongation factor GreB

Genome: KpATCC43816

Gene: greB AIK82250.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZG0
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Amino acids 157
Annotations 5
Features 25
PDB binders 0
Druggability 0.419

Overview

Basic information about this protein and its source genome.

Accession
VK055_3695
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
greB AIK82250.1
Status
annotated
Amino acids
157
Structure source
AlphaFold + ColabFold
GO
GO:0070063 Binding to an RNA polymerase molecule or complex. GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.538
DEG E-value
1.44e-63
Localization
Cytoplasmic
ColabFold pLDDT
90.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.419
Structure A0A0H3GZG0
Pocket Pocket 4
P2Rank 0.011
Structure A0A0H3GZG0
Pocket Pocket 1
ColabFold model
FPocket 0.357 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 192 / 4744 genomes with a hit
Normalized 0.04

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0070063 Binding to an RNA polymerase molecule or complex.
  • GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome.
  • GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 156 Hamap MF_00930 Transcription elongation factor GreB [greB].
1 156 InterPro IPR006358 Transcription elongation factor GreB
81 155 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term
81 155 InterPro IPR001437 Transcription elongation factor, GreA/GreB, C-terminal
2 157 NCBIfam TIGR01461 transcription elongation factor GreB
2 157 InterPro IPR006358 Transcription elongation factor GreB
3 78 SUPERFAMILY SSF46557 GreA transcript cleavage protein, N-terminal domain
3 78 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
119 135 ProSitePatterns PS00830 Prokaryotic transcription elongation factors signature 2.
119 135 InterPro IPR018151 Transcription elongation factor, GreA/GreB, conserved site
2 154 Hamap MF_00105 Transcription elongation factor GreA [greA].
2 154 InterPro IPR028624 Transcription elongation factor GreA/GreB
80 156 FunFam G3DSA:3.10.50.30:FF:000001 Transcription elongation factor GreA
80 155 SUPERFAMILY SSF54534 FKBP-like
1 76 FunFam G3DSA:1.10.287.180:FF:000001 Transcription elongation factor GreA
77 157 Gene3D G3DSA:3.10.50.30 -
77 157 InterPro IPR036953 Transcription elongation factor GreA/GreB, C-terminal domain superfamily
1 76 Gene3D G3DSA:1.10.287.180 -
1 76 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
3 156 PANTHER PTHR30437 TRANSCRIPTION ELONGATION FACTOR GREA
3 156 InterPro IPR023459 Transcription elongation factor GreA/GreB family
5 74 Pfam PF03449 Transcription elongation factor, N-terminal
5 74 InterPro IPR022691 Transcription elongation factor, GreA/GreB, N-terminal
1 157 PIRSF PIRSF006092 GreA_GreB
1 157 InterPro IPR023459 Transcription elongation factor GreA/GreB family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZG0
AlphaFold — — full sequence — Viewing
ColabFold VK055_3695
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.241
2 0.002
5 0.0
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.27 0.011