Protein profile

VK055_3745

sulfur relay protein TusC/DsrF

Genome: KpATCC43816

Gene: tusC AIK82300.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYC6
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Amino acids 119
Annotations 2
Features 16
PDB binders 0
Druggability 0.461

Overview

Basic information about this protein and its source genome.

Accession
VK055_3745
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
tusC AIK82300.1
Status
annotated
Amino acids
119
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
76.471
DEG E-value
7.16e-63
Localization
CytoplasmicMembrane
ColabFold pLDDT
96.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.461
Structure A0A0H3GYC6
Pocket Pocket 3
P2Rank 0.011
Structure A0A0H3GYC6
Pocket Pocket 1
ColabFold model
FPocket 0.067 · Pocket 3
P2Rank 0.029 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 119 Hamap MF_00389 Protein TusC [tusC].
1 119 InterPro IPR037450 Sulphur relay, TusC
2 119 Pfam PF02635 DsrE/DsrF-like family
2 119 InterPro IPR003787 Sulphur relay, DsrE/F-like
12 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 119 PANTHER PTHR38780 PROTEIN TUSC
1 119 InterPro IPR017462 Sulphur relay, TusC/DsrF
4 119 NCBIfam TIGR03010 sulfurtransferase complex subunit TusC
4 119 InterPro IPR017462 Sulphur relay, TusC/DsrF
17 119 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 119 SUPERFAMILY SSF75169 DsrEFH-like
1 119 InterPro IPR027396 DsrEFH-like
1 119 Gene3D G3DSA:3.40.1260.10 -
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYC6
AlphaFold — — full sequence — Viewing
ColabFold VK055_3745
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.034
1 0.002
4 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.27 0.011