Protein profile

VK055_3752

type IV leader peptidase family protein

Genome: KpATCC43816

Gene: AIK82308.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3X2
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Amino acids 161
Annotations 2
Features 30
PDB binders 0
Druggability 0.544

Overview

Basic information about this protein and its source genome.

Accession
VK055_3752
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82308.1
Status
annotated
Amino acids
161
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.592
DEG E-value
1.39e-30
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.544
Structure A0A0H3H3X2
Pocket Pocket 8
P2Rank 0.354
Structure A0A0H3H3X2
Pocket Pocket 1
ColabFold model
FPocket 0.805 · Pocket 8
P2Rank 0.14 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 52 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
55 74 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 151 PANTHER PTHR30487 TYPE 4 PREPILIN-LIKE PROTEINS LEADER PEPTIDE-PROCESSING ENZYME
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
138 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
29 48 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
74 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
127 137 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
86 97 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
86 97 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
98 113 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
98 113 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
18 35 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
18 35 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
75 85 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
75 85 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
55 73 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
2 125 Gene3D G3DSA:1.20.120.1220 -
14 115 Pfam PF01478 Type IV leader peptidase family
14 115 InterPro IPR000045 Prepilin type IV endopeptidase, peptidase domain
49 54 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
135 157 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
105 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
157 161 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 17 SignalP_EUK SignalP-TM SignalP-TM
20 28 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3X2
AlphaFold — — full sequence — Viewing
ColabFold VK055_3752
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.544
5 0.18
1 0.115
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.9 0.354
2 3.51 0.103
3 1.97 0.035
4 1.21 0.01