Protein profile

VK055_3787

DNA protecting protein DprA

Genome: KpATCC43816

Gene: dprA AIK82342.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWH6
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Amino acids 374
Annotations 1
Features 12
PDB binders 0
Druggability 0.584

Overview

Basic information about this protein and its source genome.

Accession
VK055_3787
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
dprA AIK82342.1
Status
annotated
Amino acids
374
Structure source
AlphaFold + ColabFold
GO
GO:0009294 The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
37.333
Localization
Unknown
ColabFold pLDDT
89.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.584
Structure A0A0H3GWH6
Pocket Pocket 10
P2Rank 0.459
Structure A0A0H3GWH6
Pocket Pocket 1
ColabFold model
FPocket 0.395 · Pocket 9
P2Rank 0.428 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009294 The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
66 282 NCBIfam TIGR00732 DNA-processing protein DprA
66 282 InterPro IPR003488 DNA recombination-mediator protein A
2 283 Gene3D G3DSA:3.40.50.450 -
6 362 PANTHER PTHR43022 PROTEIN SMF
6 362 InterPro IPR003488 DNA recombination-mediator protein A
68 274 Pfam PF02481 DNA recombination-mediator protein A
68 274 InterPro IPR003488 DNA recombination-mediator protein A
311 361 Gene3D G3DSA:1.10.10.10 -
311 361 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
78 282 SUPERFAMILY SSF102405 MCP/YpsA-like
312 357 Pfam PF17782 DprA winged helix domain
312 357 InterPro IPR041614 DprA, winged helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWH6
AlphaFold — — full sequence — Viewing
ColabFold VK055_3787
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.035
20 0.003
18 0.001
19 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.92 0.459
2 4.7 0.17
3 3.33 0.093
4 2.09 0.039
5 1.93 0.033