Protein profile

VK055_3805

fis transcriptional dual regulator

Genome: KpATCC43816

Gene: fis AIK82355.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTW9
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Amino acids 98
Annotations 5
Features 22
PDB binders 0
Druggability 0.305

Overview

Basic information about this protein and its source genome.

Accession
VK055_3805
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
fis AIK82355.1
Status
annotated
Amino acids
98
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
1.5899999999999998e-68
Localization
Cytoplasmic
ColabFold pLDDT
91.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.305
Structure A0A0H3GTW9
Pocket Pocket 3
P2Rank
Structure A0A0H3GTW9
Pocket No pockets
ColabFold model
FPocket 0.482 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 166 / 4744 genomes with a hit
Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 98 Gene3D G3DSA:1.10.10.60 -
78 98 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
78 98 InterPro IPR002197 DNA binding HTH domain, Fis-type
61 78 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
61 78 InterPro IPR002197 DNA binding HTH domain, Fis-type
4 98 SUPERFAMILY SSF46689 Homeodomain-like
4 98 InterPro IPR009057 Homeobox-like domain superfamily
1 98 PIRSF PIRSF002097 DNA-bp_Fis
1 98 InterPro IPR005412 DNA-binding protein Fis
55 95 Pfam PF02954 Bacterial regulatory protein, Fis family
55 95 InterPro IPR002197 DNA binding HTH domain, Fis-type
57 69 PRINTS PR01591 DNA-binding protein FIS signature
57 69 InterPro IPR005412 DNA-binding protein Fis
42 57 PRINTS PR01591 DNA-binding protein FIS signature
42 57 InterPro IPR005412 DNA-binding protein Fis
26 42 PRINTS PR01591 DNA-binding protein FIS signature
26 42 InterPro IPR005412 DNA-binding protein Fis
9 26 PRINTS PR01591 DNA-binding protein FIS signature
9 26 InterPro IPR005412 DNA-binding protein Fis
1 98 FunFam G3DSA:1.10.10.60:FF:000006 DNA-binding protein Fis
1 98 PANTHER PTHR47918 DNA-BINDING PROTEIN FIS
1 98 Hamap MF_00166 DNA-binding protein Fis [fis].

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTW9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3805
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.305
5 0.155
2 0.012
1 0.001